Testosterone Replacement Therapy (TRT) has become one of the most effective treatments for men experiencing low energy, reduced libido, mood swings, and declining performance. But even though TRT is widely used, one question remains the most searched and the most misunderstood:
“What is a normal weekly dose of testosterone?”
The short answer based on the scientific research by the Endocrine Society Clinical Practice Guideline:
“Most men feel their best somewhere between 75 mg and 150 mg of testosterone per week, depending on their labs, age, and how their body metabolizes the hormone.”
The long answer is what truly matters. A proper TRT dose is not just a number; it’s a balance. It must raise testosterone enough to relieve symptoms while avoiding the side effects that come from excessive dosing.
Note: TRT is a medical treatment, and it is important that you only start it once your doctor approves it. The information shared here is not medical advice. You should always consult a licensed TRT doctor before increasing or decreasing your TRT dose.
Why Your TRT Dose Matters More Than You Think
A correct dosage brings your testosterone to an optimal therapeutic level. A wrong dosage can create problems just as bad as low testosterone itself, irritability, insomnia, high estrogen, acne, or high red blood cell count.
This is why doctors personalize TRT doses. They look at your:
- Total testosterone
- Free testosterone
- SHBG
- Estradiol
- Symptoms
- Body weight
- Age
- Metabolism speed
There is no one-size-fits-all dose. But there is a clear clinical range that most men fall into.
Normal Weekly Dose of Testosterone
Here is a simple, human-friendly comparison table showing the typical dosage ranges used in medical TRT:
| TRT Category | Common Dosage | Notes |
| Low Dose/Starter | 60-100 mg/week | Often used for beginners or men with low SHBG |
| Standard TRT Dose | 100-150 mg/week | Most men feel best here |
| Higher Clinical Dose | 150-200 mg/week | Used only if labs justify it |
| Bodybuilding Dose (Not TRT) | 250 mg/week and above | Not medically safe, not TRT |
Most men on doctor-supervised TRT stay between 100 and 150 mg per week. This amount lifts testosterone into the high-normal range without overshooting into “steroid cycle” territory.
What Doctors Commonly Prescribe (By Testosterone Type)
Different forms of testosterone have slightly different timelines and absorption patterns. Here are the standard medical dosages for each.
1. Testosterone Cypionate Dosage
It is the most prescribed TRT medication in the U.S.
Typical dose: 80–150 mg per week
Common schedule: Once weekly or twice weekly
This ester provides a smooth release and stable levels, especially when split into two injections.
2. Testosterone Enanthate Dosage
It works almost exactly like cypionate.
Typical dose: 100–150 mg per week
Schedule: Weekly or twice weekly
Most patients can switch between enanthate and cypionate without any noticeable difference.
3. Subcutaneous (SubQ) Testosterone Dosage
SubQ dosing is becoming popular because it uses a smaller needle and can reduce fluctuations.
Typical SubQ dose:
15–30 mg per injection, given 2–4 times per week
SubQ works very well for men with low SHBG or men sensitive to estrogen spikes.
Weekly vs. Twice-Weekly TRT Injections: What’s Better?
Some men do fine with one weekly shot. Others feel waves: a strong high after the injection, followed by a dip later in the week.
| Schedule | Pros | Cons |
| Once Weekly (e.g, 120 mg per week) | Easy, fewer injections | Bigger peaks & valleys; higher estrogen conversion |
| Twice Weekly (e.g., 60 mg × 2) | Most stable levels; fewer side effects | Requires more planning |
| Microdosing (20–30 mg EOD) | Ultra-stable; great for low SHBG | More Injections per week |
What Is the Best TRT Dose for Beginners?
Most physicians start beginners with a moderate dose:
1. Beginner TRT Dose:
80–120 mg per week
This gives your body time to adjust and keeps estrogen conversion manageable.
Why doctors don’t start with a high dose:
- Avoid sudden spikes
- Lower chance of acne or irritability
- Easier to adjust upward than downward
- Reduces the risk of elevated hematocrit
Beginning TRT is about finding your balance, not rushing.
TRT Dose for Low Testosterone (Men Over 30, 40, 50)
Low testosterone affects men differently at different ages.
1. Men in their 30s:
Often need 100–140 mg/week to counter metabolic demand.
2. Men in their 40s:
May need slightly less because estrogen conversion increases with age. Common dose: 80–120 mg/week
3. Men above 50+
Tend to metabolize testosterone more slowly.
Typical dose: 70–110 mg/week
Age impacts dosage — not because testosterone “should” be lower, but because metabolism changes.
How to Know If Your TRT Dose Is Too High
A high dose is more common than people think. Many men assume that more testosterone equals more benefits, but that is not how hormone therapy works.
Signs your dosage is too high:
- Irritability or mood swings
- Trouble sleeping
- Acne or oily skin
- Excessive sex drive followed by a crash
- Increased blood pressure
- Headaches
- High hematocrit
- Puffy or bloated feeling
- Elevated estradiol
If you are experiencing these, your dose may be too high, or your injection frequency may need adjustment.
How to Know If Your TRT Dose Is Too Low
A dose can be too low even if your testosterone increases a little.
Signs of a low dose:
- Low energy
- Weak libido
- Soft or weak erections
- No improvement in sleep or mood
- Slow progress in strength or muscle tone
- Testosterone staying below 600 ng/dL
- Low free testosterone
- Persistent brain fog
A low dose often means your body isn’t reaching the “therapeutic zone.”
Medically Safe TRT Dose
A medically safe TRT dose is any dose that keeps blood levels in the high-normal range for adult males while maintaining healthy markers.
Most physicians agree that 50–200 mg per week is the clinical safety range for TRT.
Above this range, the risk of side effects increases significantly.
The real secret:
It’s not the dose that determines safety: It’s the bloodwork.
Key Takeaway
- Most men feel optimal on a TRT dose of 75–150 mg per week.
- TRT dosing is individualized and based on labs, symptoms, and metabolism.
- Splitting injections improves stability and reduces side effects.
- Beginners should start low to avoid estrogen and hematocrit issues.
- Bloodwork determines safety, not the milligram dose.
Disclaimer: The content shared above is only for informational purposes. It is not medical advice. Always consult your doctor before deciding on your TRT dose.
