CJC-1295 + Ipamorelin Peptide Therapy: Dosage, Injection Sites, Benefits & Results (2026 Guide)

Peptide-based therapies like CJC-1295 combined with Ipamorelin have become widely discussed in anti-aging, body-composition, and recovery communities. 

This guide explains how the CJC-1295 + Ipamorelin combination works. It summarizes the available human research. It also outlines commonly used dosing and administration practices. The guide also describes where to inject Ipamorelin and where to inject CJC-1295. Finally, it covers the benefits, risks, and realistic expectations for results.

What are CJC-1295 and Ipamorelin?

CJC-1295 is a synthetic analogue of growth-hormone-releasing hormone (GHRH). When formulated as the albumin-binding version (often called “DAC”), it has a long half-life (measured in days) and produces prolonged increases in growth hormone (GH) and IGF-I after subcutaneous injection. 

Clinical studies show a single CJC-1295 dose can raise mean plasma GH by 2–10× for ~6+ days and IGF-I by ~1.5–3× for 9–11 days.

Ipamorelin is a selective ghrelin-receptor agonist (a growth-hormone secretagogue). It triggers pulsatile GH release without substantially increasing ACTH or cortisol in preclinical work, and has been investigated in human trials for safety in specific clinical settings. 

Clinical trials have used weight-based dosing (for example, 0.03 mg/kg twice daily in a proof-of-concept surgical trial).

Together, the two act synergistically: CJC-1295 stimulates GHRH pathways and sustains GH/IGF-I increases, while Ipamorelin promotes pulsatile GH secretion via ghrelin receptor activation. 

Many clinicians and peptide-therapy proponents pair them to get both amplitude and frequency stimulation of GH release.

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Scientific Evidence: What the Studies Say

Human trials of CJC-1295 demonstrated durable, dose-dependent increases in GH and IGF-I with an estimated half-life for the albumin-binding form around 5.8–8.1 days; repeated dosing produced sustained IGF-I elevation for weeks. 

These were randomized, controlled trials in healthy adults. 

For ipamorelin, several clinical studies and trials looked at its safety and targeted uses (e.g., gastrointestinal prokinetic effects, postoperative ileus). 

A clinical proof-of-concept trial used 0.03 mg/kg twice daily for short durations and found the drug to be generally well tolerated, though efficacy endpoints were mixed depending on the indication. 

Key numeric takeaways from peer-reviewed work:

• CJC-1295 (long-acting): half-life ≈ 5.8–8.1 days; GH increased 2–10×, IGF-I increased ~1.5–3× after a single dose in trials. 

• Ipamorelin dosing used in clinical trials: 0.03 mg/kg (30 mcg/kg) twice daily in some studies; clinical outcomes depended on the condition studied.

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1. B-12 (Cyanocobalamin)

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6. GHK-CU

7. Glutathione/NAD +

Typical (community) Dosing Protocols For CJC-1295 and Ipamorelin

Clinical trials and community protocols differ. CJC-1295 clinical dosing in trials used microgram/kg regimens (e.g., doses like 30–60 µg/kg in early research). The long-acting (DAC) form is given much less frequently (weekly or biweekly) in clinical research. Ipamorelin in trials has been dosed by weight (see above).

In practice (community / clinician-led protocols commonly observed online), a frequently used stack is:

• Ipamorelin: 100–300 mcg per injection, 1–3 times daily (common: morning and before sleep).
  
• CJC-1295 (no DAC): 100–200 mcg per injection, 1–2 times daily; or
  
• CJC-1295 (DAC): single weekly dose (microgram-per-kg style dosing in clinical formulations).
  

These community protocols vary widely; they are not standardized and are not the same as controlled clinical trial regimens. 

Where to inject Ipamorelin and Where to inject CJC-1295 (injection-site guidance)

Both peptides are administered subcutaneously (under the skin). Standard subcutaneous injection sites recommended by oncology and clinical education centers are the same for most subcutaneous drugs and include:

• Abdomen (belly) — avoid a 1–2 inch circle around the navel; rotate injection points.
  
• Upper outer thighs (middle front or outer middle).
  
• Upper buttocks / gluteal area (upper outer quadrant).
  
• Back of the upper arms (if someone else is giving the injection).
  

These are the typical subcutaneous injection sites used for self-administration; absorption is reliable, and pain is typically minimal if proper technique is used (pinch the skin, insert at ~45–90° depending on needle length). For a step-by-step technique, see standard patient education materials.

Practical tips:

• Rotate sites daily to avoid lipohypertrophy or localized irritation.
  
• Clean the skin with alcohol, let it dry, pinch a fold of skin, insert the needle, inject slowly, withdraw, and press for a few seconds.
  
• Use the correct needle length (commonly short insulin-type needles for subcutaneous injections).
  
• Do not inject intramuscularly or into bruised / inflamed tissue.
  
  

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Benefits People Expect (and what trials support)

Reported or studied effects of CJC-1295 + Ipamorelin or each peptide individually include:

• Increased GH and IGF-I levels (documented in trials for CJC-1295; ipamorelin stimulates GH pulses).
  
• Improvements in body composition (increased lean mass, reduced fat mass) have been observed in some research models and are cited in preclinical and clinical literature, though robust, large RCT data for aesthetic/bodybuilding uses are limited.
  
• Sleep and recovery: users and some studies report improved sleep quality and recovery metrics; objective evidence varies.
  
• Skin / anti-aging: anecdotal reports and small studies suggest possible skin quality improvement mediated via IGF-I and GH pathways—but high-quality long-term data is sparse.
  

Be realistic: clinical trials primarily assess hormonal changes and safety, not the full spectrum of aesthetic claims. Many high-impact outcome claims come from small studies or community reports rather than large RCTs.

Risks and Safety Concerns

No drug is risk-free. Important safety points:

• Regulatory status: Many injectable peptides (including CJC-1295 and Ipamorelin in their research forms) are not FDA-approved for general wellness/anti-aging use and are often sold as “research chemicals.” Media and medical bodies have warned about the risks of unregulated peptide use, mislabeling, and contamination. 

• Quality control: Because many peptides are sold online from non-regulated suppliers, contamination, incorrect dosing, or impure products are real risks. News outlets and health authorities have raised concerns about self-administration outside medical supervision. 

• Bottom line on safety: If someone considers peptide therapy, it should be under medical supervision with pre-treatment screening (baseline GH/IGF-I, metabolic panel, glucose), ongoing monitoring, and sourcing from reputable, traceable suppliers under a lawful framework.

Realistic Timeline and Expected Results

• Hormonal changes: CJC-1295 (long-acting) can elevate GH and IGF-I within days and maintain higher trough levels for 1–4+ weeks after dosing in trial settings. Ipamorelin produces more immediate, pulsatile GH releases after injection.
  
• Visible/functional effects: Body-composition and recovery changes (if they occur) typically appear over weeks to months with consistent use, plus nutrition and training. Claims of dramatic short-term transformations are often exaggerated by marketing.
  

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